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Pathology and Laboratory Medicine
Product Catalogue


Transfusion Medicine

​Alternate Product Names
  • ​Cryo
  • ​Fibrinogen replacement in congenital hypofibrinogenemia or dysfibrinogenemia
  • Congenital hypofibrinogenemia
  • Acquired hypofibrinogenemia and bleeding:
    • Coagulopathic patients who have a  fibrinogen level <1.5 g/L
    • Obstetrical patients with uncontrolled bleeding who have a fibrinogen level <2 g/L
  • Factor XIII replacement in the setting of factor deficiency
​Resource Information
Size/Volume Available
  • 5 – 15 mL per unit
Pre -Transfusion Testing Requirements
  • ​ABO Group and Rh Type on current admission
    • Contact Transfusion Medicine prior to collection to confirm
Forms Required


  • Indicate number of units required
    • Dose guideline:  1 unit per 10 kg (average single adult dose is 8-10 units) 
  • ​Rh compatibility not required
    • ABO compatibility preferred but not always available
  • Allow approximately 20 minutes for product to be thawed and pooled
    • Preparation of cryoprecipitate for infusion includes the addition of 10 mL 0.9% Sodium Chloride to facilitate product pooling
    • Approximate product equivalency for replacement of 1 gram of fibrinogen:
Product Component​Size​Volume
​Fibrinogen concentrate
​1 vial ( 1 gram)​50 mL (reconstituted)
​Cryoprecipitate​3 units​30 mL
​Plasma (FP or FFP)​1 unit
​350 mL
  • Choice of product for fibrinogen replacement and target fibrinogen level is a clinical decision based on patient condition
  • Available upon request during a Massive Transfusion Protocol, dependent on serum fibrinogen level or thromboelastograph (TEG) suggestive of hypofibrinogenemia


​If you choose to print this information, it is valid only on date of print.

Laboratory Controlled Document LSM-57 v6

Last Modified: Thursday, January 21, 2021 |
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