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Pathology and Laboratory Medicine
Product Catalogue

​Fibrinogen Concentrate

Transfusion Medicine

​Indications
  • ​Treatment of acute bleeding in congenital fibrinogen deficiency
  • Treatment of acute bleeding in acquired fibrinogen deficiency (off-label)
​Resource Information
​Product Monographs:

More Information:

​Pre-Transfusion Testing Requirements
  • ​None required

Availability
Product Size
​RUH ​SCH ​SPH
Rural
​1 gm
Yes​​Yes
​Yes
​No
Ordering

  • Consultation with Transfusion Medical Director required
  • Indicate volume required

Forms Required

​Saskatoon:

Alternate Product Names
  • RiaSTAPTM
Notes
  • Pasteurized, preservative-free, lyophilised human fibrinogen concentrate
  • Manufacturing effectively protects against enveloped viruses, including HIV, HBV, and HCV, and the non-enveloped virus HAV
  • Contains: 0.9-1.3 grams fibrinogen per vial
  • Stored at 2-8oC (Note: the sterile water for injection included with the product must be stored at 20-25oC)
  • Half-life ~77 hours (in vivo)
  • Approximate product equivalency for replacement of 1 gram of fibrinogen:

​Product/Component

​Size

​Volume

​Fibrinogen Concentrate (RiaSTAPTM)
​1 vial (1 gram)
​50 mL (reconstituted)
​Cryoprecipitate
​3 units
​30 mL
​Plasma (FP or FFP)
​1 unit
​350 mL
  • Consideration for use as an adjunct to treatment of profound acquired hypofibrinogenemia with clinically significant hemorrhage, including:
    • Disseminated Intravascular Coagulation (DIC)
    • Obstetrical hemorrhage
  • There is no evidence of fibrinogen concentrate (RiaSTAPTM) superiority over plasma or cryoprecipitate administration for fibrinogen replacement
  • Choice of product for fibrinogen replacement and target fibrinogen level is a clinical decision based on patient condition
  • Pediatric patients - (RiaSTAPTM) may exhibit a shorter half-life due to increased clearance

​Administration
  • See product monograph
  • Contains human protein; informed patient consent required for this product
  • Maximum intravenous infusion rate of 5 mL per minute (100 mg/minute; 1 reconstituted vial over 10 minutes)
  • Administer within 8 hours of reconstitution



​If you choose to print this information, it is valid only on date of print.

Laboratory Controlled Document LSM-844 v4

Last Modified: Wednesday, October 16, 2019 |
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