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Pathology and Laboratory Medicine
Product Catalogue

​Fibrinogen Concentrate

Transfusion Medicine

​Alternate Product Names
  • ​RiaSTAP™
​Indications
  • ​Treatment of acute bleeding in congenital fibrinogen deficiency
  • Treatment of acute bleeding in acquired fibrinogen deficiency (off-label)
​Resource Information
​Product Monographs:

More Information:

Availability
Product Size
​RUH ​SCH ​SPH
Rural
​1 gm
Yes​​No​No​No
Pretransfusion Testing Requirements
  • ​None required
Forms Required

​Saskatoon:

Ordering
  • Consultation with Transfusion Medical Director required
  • Indicate volume required
​Notes
  • ​Pasteurized, preservative-free, lyophilised human fibrinogen concentrate
  • Manufacturing effectively protects against enveloped viruses, including HIV, HBV and HCV, and the non-enveloped virus HAV
  • Contains 0.9-1.3 grams of fibrinogen per vial
  • Stored at room temperature
  • Half-life ~77 hours (in vivo)
  • Approximate product equivalency for replacement of 1 gram of fibrinogen:
Product/ComponentSizeVolume
​Fibrinogen concentrate (RiaSTAP™)​1 vial (1 gram)
​50.0 mL (reconstituted)
​Cryoprecipitate​3 units
​30.0 mL
​Plasma (FP or FFP)​1 unit
​350.0 mL
  • Consideration for use as an adjunct to treatment of profound acquired hypofrinogenemia with clinically significant hemorrhage, including:
    • Disseminated Intravascular coagulation (DIC)
    • Obstetrical hemorrhage
  • There is no evidence of fibrinogen concentrate (RiaSTAP™) superiority over plasma or cryoprecipitate administration for fibrinogen replacement
  • Choice of product for fibrinogen replacement and target fibrinogen level is a clinical decision based on patient condition
  • Pediatric patients – RiaSTAP™ may exhibit a shorter half-life due to increased clearance
Administration
  • ​See product monograph
  • Contains human protein; informed patient consent required for this product
  • Maximum intravenous infusion rate of 5 mL per minute (100 mg/minute; 1 reconstituted vial over 10 minutes)
  • Administer within 8 hours of reconstitution

​If you choose to print this information, it is valid only on date of print.

Laboratory Controlled Document LSM-844 v2

Last Modified: Friday, July 7, 2017 |
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