• ​Bleeding or prior to a significant operative procedure in patients with multi-coagulation factor deficiency when no coagulation factor concentrates or alternative therapies are appropriate or available. (i.e. liver disease, DIC)
• INR greater than or equal to 1.7 and increased PTT
• Single factor deficiencies for which no concentrate is available (i.e. Factor V)
• Massive transfusion
• Therapeutic Plasma Exchange in Thrombotic Thrombocytopenia Purpura (TTP), if cryosupernatant plasma is unavailable
• Urgent warfarin reversal in patients experiencing major bleeding or requiring urgent surgery if there is a contraindication to prothrombin complex concentrates (PCC), or if PCC are unavailable 

• Plasma transfusion is NOT appropriate in the following situations:
• As a volume expander or nutritional supplement
• Treatment of factor deficiency if recombinant or plasma derived, virally inactivated products are available
• Treatment of an isolated high INR in the setting of liver failure prior to procedure
• Treatment of a mildly elevated INR (less than 1.8) for any reason prior to procedure or in the setting of bleeding
• Elevated INR at any value, in the absence of bleeding
• Warfarin reversal, if PCC is available
• Reversal of heparin, LMWH, direct factor II inhibitor, or direct factor Xa inhibitor

• Volume indicated on unit

​Saskatoon/Humboldt:

• Blood Product Request Form# 103220

Rural:

• Contact your site laboratory
  

• Rh compatibility not required
• Frozen Plasma (FP) and Fresh Frozen Plasma (FFP) are considered equivalent in terms of clinical efficacy
• Issue of FP versus FFP units will be an inventory management decision by the Transfusion Medicine Laboratory
• Plasma volume indicated on lower left corner of product label
• Plasma shall be issued one unit at a time depending on the clinical situation (exception – during a MTP activation)
• Do not send for product prior to obtaining patient’s informed consent being obtained or line placement
• Patients who have repeated allergic-type reactions or a severe transfusion adverse event with plasma transfusion may be eligible to receive solvent-detergent plasma (Transfusion Medicine Physician approval is required for S/D plasma)