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​Prothrombin Complex Concentrate (PCC)

Transfusion Medicine

​Alternate Product Names
  • ​Beriplex
  • Octaplex
  • PCC
  • ​Urgent reversal of warfarin in patients with an INR of 1.5 or greater with:
    • Major bleeding and/or
    • Need for an unplanned surgical procedure which cannot be delayed a minimum of 6 hours
  • Consideration for management of factor Xa inhibitor (apixaban (Eliquis®), rivaroxaban (Xarelto®), or edoxaban (Lixiana®) associated bleeding. See “Dosing” and “Notes” sections below and/or consult the Transfusion Medicine Physician on-call.
  • Patients with a known heparin allergy or in suspected or proven Heparin Induced Thrombocytopenia (HIT)
  • IgA deficiency with anti-IgA antibodies (applies to Octaplex® only)

  • Not effective for management of:
    • Disseminated Intravascular Coagulopathy (DIC)
    • Liver dysfunction/disease associated coagulopathy
    • Massive transfusion
    • Bleeding associated with heparin based anticoagulants, antiplatelet agents or direct thrombin inhibitors (dabigatran/Pradaxa)
​Resource Information

​Product Monographs:

More Information:

Size/Volume Available
  • 500 IU (20 mL)
  • 1000 IU (Octaplex only)


*Note: Rosthern and Humboldt maximum stock availability is 2000 IU
Pretransfusion Testing Requirements
  • ​None required
Forms Required


  • Warfarin Reversal for Major Bleeding or Urgent Surgery
​INR 1.5-2.9
INR 3.0-5.0
INR 5.1 or greater
PCC dosage
​1000 IU
​2000 IU
​3000 IU
    •  If the INR is unknown and major bleeding is present in a patient known to be taking warfarin, 2000 IU (80 mL) PCC should be administered
    • Maximum dose not to exceed 3000 IU
  • Factor Xa Inhibitor Bleeding Management
AnticoagulantBeriplex®/Octaplex® Dose​
​Apixaban (Eliquis®)25-50 IU/kg x 1​
​Rivaroxaban (Xarelto®)25-50 IU/kg x 1​
    • Maximum dose not to exceed 3000 IU
    • Contraindicated in patients with a history of Heparin Induced Thrombocytopenia (HIT)
  • Warfarin Reversal for Major Bleeding or Urgent Surgery
  • Direct Oral Anticoagulant (DOAC) Associated Bleeding
  • Adverse reactions including immediate allergic complications are rare. Thrombosis risk is at least 1 in 100, and dependent on individual patient risk factors and PCC dose.
  • ​Administration information can be found in the Nursing Policy and Procedure Manual, the product monograph/package insert and the applicable site Job Aid
  • Must be infused within  3 hours of reconstitution
  • Contains human protein; informed patient consent required for this product
  • A Transfusion Medicine/CBS chart report is NOT required for product infusion


​If you choose to print this information, it is valid only on date of print.

Laboratory Controlled Document LSM-342 v8

Last Modified: Friday, January 26, 2018 |
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