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Pathology and Laboratory Medicine
Transfusion Essentials

​Special Requirements for Blood Products

​Special Requirement
​Eligible Patients
Irradiated  Cellular Blood Components

  • Low birth weight premature newborns (<1200 g) until 4 months of age
  • History of intrauterine transfusion, until 6 months after the initial expected delivery date (40 weeks gestational age) 
  • Neonatal exchange transfusion
  • Directed donations
  • HLA matched components
  • Allogenic stem cell/bone marrow transplant recipients (from start of conditioning chemotherapy, for life after transplant)
  • Autologous stem cell/bone marrow transplant recipients (from 7 days before the start of stem cell mobilization, until 6 months post-transplant)
  • Allogeneic stem cell donors (7 days prior to collection and during the collection process only)
  • Chimeric Antigen Receptor T-Cell (CAR-T) Therapy recipients (from start of conditioning chemotherapy, for life after therapy)
  • Congenital T-cell immune deficiency (DiGeorge syndrome, SCID)
  • Hodgkin’s Lymphoma, for life
  • Patients receiving or who have received the following (for life, from the time of drug initiation):
    • Anti-thymocyte globulin (ATG; Thymoglobulin, Atgam)
      • If given for severe aplastic anemia or conditioning prior to allogeneic bone marrow transplant
    • Alemtuzumab (Campath, Lemtrada)
    • Bendamustine (Treakisym, ribomustin, Levact and Treanda)
    • Cladribine/2-CDA (Leustatin)
    • Clofarabine (Clolar)
    • Deoxycoformicin/Pentostatin
    • Fludarabine (Fludara)

CMV Negative Cellular Blood Components
  • ​Intrauterine transfusion (not available in Saskatchewan)

All blood components in Canada have undergone pre-storage leukoreduction and are considered “CMV safe”. Transfusion of leukoreduced plus CMV seronegative blood components has not been identified to provide additional protection against transfusion-transmitted CMV. 

Apheresis platelets
  • ​Aplastic anemia
  • Congenital marrow failure disorders (Diamond Blackfan anemia, Fanconi anemia)
  • Pediatric patients requiring less than 200 mL
  • Neonates ( < 4 month old)
  • Patients meeting requirements for HLA or HPA Matched platelets (see below)
HLA Matched Apheresis Platelets
  • Patients with HLA antibodies and demonstrated platelet refractoriness
HPA Matched Apheresis Platelets
  • Patients with HPA1a (PLA1) antibodies
  • Neonates with Neonatal Alloimmune Thrombocytopenia (NAIT)
  • Patients with history of Post Transfusion Purpura (PTP)
Phenotype Matched Red Blood Cells for Rh and Kell (prophylactic antigen matching as per local policy)
  • ​Aplastic anemia, pure red cell aplasia
  • Congenital marrow failure disorders (Diamond Blackfan anemia, Fanconi anemia)
  • Sickle cell anemia
  • Thalassemia
Washed Red Blood Cells
  • ​Neonates with high potassium levels and/or requiring large volumes transfusion
  • Patients who experience recurrent, severe allergic reactions
  • IgA deficient patients with anti-IgA antibodies or history of severe reaction to transfusions
  • Patients with a history of PTP, if HPA-matched donor red blood cells are unavailable

If you choose to print this information, it is valid only on date of print.

Laboratory Controlled Document LSM-795 v4

Last Modified: Thursday, October 6, 2022 |
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